The state-of-the-art infrastructure of CESAR facilitates the development of novel antibiotics for medicine. Functionality of the infrastructure was verified in a first R&D project termed "VISA". In the future, the infrastructure of CESAR will be used for collaborations with academic and industry partners.
VISA - Verification of the Infrastructure for Antibiotic Research
CESAR aims to identifiy and isolate novel compounds from producers of natural substances for antibiotic screening and structural analysis. CESAR additionally allows to analyse the mode of action and target of promising candidates as well as initial pharmacological and pharmacokinetic evaluation.
Verification of the infrastructure was perfomed at three levels of increasing difficulty. Starting with the isolation of already known antibiotics produced by bacteria, followed by a metabolomic-based identification of novel natural derivatives of these compounds. Finally, the search for novel antibiotic classes was established using environmental isolates of Streptomycetes.
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Last update: Jul 09, 2024